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Systems Biology: Principles, Methods, and ConceptsFrom CRC Press
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With extraordinary clarity,the Systems Biology: Principles, Methods, and Concepts focuses on the technical practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer science, and dynamical systems, it explores pragmatic techniques of General Systems Theory. This text presents biology as an autonomous science from the perspective of fundamental modeling techniques. A complete resource for anyone interested in biology as an exact science, it includes a comprehensive survey, review, and critique of concepts and methods in Systems Biology.
- Sales Rank: #3704130 in Books
- Published on: 2006-11-20
- Original language: English
- Number of items: 1
- Dimensions: 10.14" h x .77" w x 7.22" l, 1.38 pounds
- Binding: Hardcover
- 256 pages
Most helpful customer reviews
1 of 2 people found the following review helpful.
Most interesting! Terrific text for experts and novices alike.
By Margaret J
I am impressed by the depth and skills with which difficult topics are handled by the authors of individual chapters as well as by the Editor. Introductory chapter 1 is indeed a state-of-the-art vision of systems biology for today's biologists, chemists, and engineers. The entire book is masterfully written by most competent experts and academic teachers available today. Notably the chapter about chaos (Chapter 6) is the best text on the topic I have read thus far in my long life (I'm not very young and I've read scores of publications about non-linear phenomena.) Chapters written under the leadership of Prof. Salamon (Chapters 3 and 9) are most convincing texts about macroscopic thermodynamics that are accessible to general readers as well as to the experts. (I guess Chapter 9 is for the experts because of the required mathematical background.) Biochemical Systems Theory is a subject of Chapter 2, which in itself is an interesting text in systems biochemistry including its (long) history. Chapter 5 introduces a concept of organic system, while discussing problems of ecological networks. This notion (organic system) is of great importance for systems biology because not every organic system needs to be a living entity. From the point of view of scientific method, organic properties (of organic systems) can be treated by the techniques analogous to dynamic systems but the organic properties (initial and boundary conditions) are not compatible with those known from physics. In a way organic systems could be a methodological bridge between classical science and modern systems biology. The remaining chapters cover engineering aspects of systems biology (chapters 6 and 7) as well as a history of philosophical investigations relevant to life sciences (Chapter 4.)
The book is very much worth reading by anyone interested in science (particularly in biology.)
3 of 4 people found the following review helpful.
Outstanding state-of-the-art text-handbook-monograph in one short volume
By Hubert from Baltimore
This text should be recommended to every student of systems biology and, for that matter, to most practicing biologists who are interested in profound understanding of systems methodology in life sciences. The book focuses on and explores the very foundations of modeling complex organic systems from the perspectives that in the past were called "cybernetics", "systems science", "General Systems Theory", or "Relational Biology". It does however contain two state-of-the-art chapters on thermodynamics, one on biochemical kinetics, and one on non-linear dynamics; topics that are also covered in a number of other systems biology books. The methodology of dealing with networks is covered as well but to a lesser extent than in many other systems biology texts. The glossary of terms from a variety of different fields that contribute to systems biology is also included, such that the book can be used by self-learners.
Overall the book is a great achievement of a group of world-class top experts who contributed definitive chapters in their respective sub-fields of systems biology. I highly recommend this text as a valuable reading for all readers who wish to understand the phenomenon of life itself from a scientific point of view.
3 of 4 people found the following review helpful.
Really good book on the topic
By A. Ciapata
This is an important book (I agree with another reviewer about this.) It covers all needed foundations of today's systems biology in a non-trivial way. It also contains a definitive guidance on terminology of systems theory and relational biology; something most other books with "systems biology" in the title are missing. It is true that (perhaps intentionally) the use of networks is only emphasized in one chapter (Chapter 5)while the ideas from thermodynamics, general systems theory and relational biology are explained in detail in several other chapters. That's why (I agree again with another reviewer) readers of this book who wish to study systems biology could greatly benefit from a supplementary reading of a good text on networks. On the other hand readers with some expertise in science and those who are familiar with networks will likely find a lot of intellectual satisfaction from reading this relatively short book from cover to cover.
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